“Defining an index for cellular senescence”
Seed Corn Funding from EPSRC (Engineering and Physical Sciences Research Council) and Wellcome Trust
Ageing is a critical economic, social and medical challenge. Senescent cells provide a good model to study ageing. However, cultures of ‘senescent’ cells are a mix of cell populations (proliferative, senescent and growth arrested cells). Determining the proportion of genuinely senescent cells is crucial. The ability to compare the efficacy of anti-senescent therapies relies on accurate measures of senescence.
Commonly used senescence markers are diverse and with none purely specific for senescence. Therefore, our aim is to merge these markers to build a reliable senescence index, which may be used to compare the level of senescence in cell cultures. This project would develop a new and innovative methodology to study cell senescence. The results would contribute useful tools to understand how a cell culture ages.